Cotrimoxazole (Sulfamethoxazole + Trimethoprim)


Co-trimoxazole is nothing more than the combination of sulfamethoxazole (a sulfonamide) and trimethoprim (another antibacterial) in a fixed ratio of 5: 1.
Most likely, this combination of active ingredients is better known under the trade name of Bactrim®.

Sulfamethoxazole - Chemical Structure

Trimethoprim - Chemical Structure

Unlike the single active ingredients that possess bacteriostatic activity (ie they are able to inhibit bacterial growth), their association allows to obtain a "bactericidal action (ie, when used together, they are able to kill bacterial cells). .
Co-trimoxazole is available in pharmaceutical formulations suitable for both oral and parenteral administration.


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