Factors that modify the distribution of drugs

The distribution of a drug in the organism can be influenced by various factors related to the subject. We recall that we speak of distribution to indicate the process by which a drug passes from one part of the body to another until it reaches the site of action.

Age

Hypoalbuminemia in the elderly and in the newborn; presence of fetal albumin with reduced binding capacity in the newborn; presence of endogenous displacing metabolites in the elderly and in the newborn.

Pregnancy

Hypoalbuminemia; variations in the volumes of the body water compartments.

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Deterioration of circulatory function.

Liver diseases

Hypoalbuminemia; accumulation of endogenous metabolites displacing.

Nephropathies

Hypoalbuminemia; reduction of the binding capacity of albumin.

Severe burns, infectious and inflammatory diseases, trauma, surgery, neoplasms, ulcerative colitis.

Hypoalbuminemia; increase in the concentration of orosomucoid (protein of the acute phase of inflammation that binds various drugs).

 


Other articles on "Factors that change drug distribution"

  1. Binding of a drug to plasma proteins
  2. Distribution of a drug
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