Factors that modify the distribution of drugs
The distribution of a drug in the organism can be influenced by various factors related to the subject. We recall that we speak of distribution to indicate the process by which a drug passes from one part of the body to another until it reaches the site of action.
Hypoalbuminemia in the elderly and in the newborn; presence of fetal albumin with reduced binding capacity in the newborn; presence of endogenous displacing metabolites in the elderly and in the newborn.
Hypoalbuminemia; variations in the volumes of the body water compartments.
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Deterioration of circulatory function.
Hypoalbuminemia; accumulation of endogenous metabolites displacing.
Hypoalbuminemia; reduction of the binding capacity of albumin.
Severe burns, infectious and inflammatory diseases, trauma, surgery, neoplasms, ulcerative colitis.
Hypoalbuminemia; increase in the concentration of orosomucoid (protein of the acute phase of inflammation that binds various drugs).
Other articles on "Factors that change drug distribution"
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- Distribution of a drug