CRYSTACIDE ® Hydrogen peroxide

CRYSTACIDE ® is a drug based on hydrogen peroxide

THERAPEUTIC GROUP: Antiseptics and disinfectants

Indications CRYSTACIDE ® Hydrogen peroxide

CRYSTACIDE ® is indicated in the treatment of skin infections caused by microorganisms sensitive to hydrogen peroxide.

Mechanism of action CRYSTACIDE ® Hydrogen peroxide

Hydrogen peroxide, the active ingredient of CRYSTACIDE ®, is a highly reactive oxygen free radical with an intense oxidizing power capable of altering the normal structures and functions of the biomolecules, thus exerting a bacteriostatic and weakly bactericidal action.
Generally it is the interaction of the peroxide with the proteins and nucleic acids of the bacterial element that determines a reduction in the vital capacity of the latter, thus compromising both the normal metabolic and replicative processes, thus limiting the proliferation and spread of the species pathogenic.
The aforementioned bacteriostatic activity, safe when carried out on non-closed areas, has proved effective against Gram positive, Gram negative and some fungi, thus defining a fairly broad spectrum of action that allows its optimal use in the clinical setting. .

Studies carried out and clinical efficacy

Panminerva Med. 2010 Jun; 52 (2 Suppl 1): 11-4.

Faster healing of venous ulcers with crystacide: a clinical and microcirculatory 8-week registry study.

Cesarone MR, Belcaro G, Errichi BM, Ricci A, Bavera P, Ippolito E, Dugall M.

Very interesting study that demonstrates how the skin application of hydrogen peroxide, improving the hemodynamic characteristics of the microcirculation, can facilitate the healing of ulcers in affected patients

Curr Med Res Opin. 2003; 19: 135-8.

Efficacy and safety of stabilized hydrogen peroxide cream (Crystacide) in mild-to-moderate acne vulgaris: a randomized, controlled trial versus benzoyl peroxide gel.

Milani M, Bigardi A, Zavattarelli M.

Italian study that demonstrates how the cutaneous application of hydrogen peroxide can improve the extent of inflammatory and non-inflammatory lesions in patients with acne vulgaris.

Angiology. 2003 May-Jun; 54: 325-30.

Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide. Evaluation of free radicals, laser Doppler flux and PO2. A prospective-randomized-controlled study.

Belcaro G, Cesarone MR, Nicolaides AN, Geroulakos G, Di Renzo A, Milani M, Ricci A, Brandolini R, Dugall M, Ruffini I, Cornelli U, Griffin M.

Yet another study that evaluates the effectiveness of hydrogen peroxide in improving hypertension of the venous limbs, reducing the risk of the formation of venous ulcers and at the same time facilitating their healing.

Method of use and dosage

1% hydrogen peroxide cream for skin use.
Generally it is recommended to apply the correct amount of cream on the skin region to be treated, 2-3 times a day, taking care not to prolong the treatment for more than three weeks.

Warnings CRYSTACIDE ® Hydrogen peroxide

The application of CRYSTACIDE ® should be limited to infected skin and for short periods of time, since repeated skin applications could give rise to sensitization phenomena, tissue discoloration and local or systemic adverse reactions.
It is also recommended to avoid contact with exposed eyes and mucous membranes as well as with deep skin lesions.
Store CRYSTACIDE ® in a cool, dry place out of the reach of children.


The use of CRYSTACIDE ® during pregnancy should be limited to cases of unavoidable necessity and constantly supervised by your gynecologist.


It is recommended to avoid the simultaneous use of other skin or systemic oxidants.

Contraindications CRYSTACIDE ® Hydrogen peroxide

The use of CRYSTACIDE ® is contraindicated in patients hypersensitive to the active substance or to one of its excipients.

Undesirable Effects - Side Effects

The use of CRYSTACIDE ® is generally safe and well tolerated.
Only rarely is it possible to perceive a slight burning sensation, while even more rare are the adverse reactions of hypersensitivity to the active ingredient.


CRYSTACIDE ® is a drug not subject to mandatory medical prescription.

The information on CRYSTACIDE ® Hydrogen Peroxide published on this page may be out of date or incomplete. For a correct use of this information, see the Disclaimer and useful information page.

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