NEOXENE ® Chlorhexidine

NEOXENE ® is a drug based on Chlorhexidine Digluconate

THERAPEUTIC GROUP: Antiseptics and disinfectants

Indications NEOXENE ® Chlorhexidine

NEOXENE ® is generally indicated for the disinfection of injured skin and for general and hand antisepsis.
NEOXENE ® in eggs is instead indicated for the disinfection of the vaginal environment.

Mechanism of action NEOXENE ® Chlorhexidine

NEOXENE ® is a drug based on Chlorhexidine, a structurally complex molecule consisting of a bivalent chemical structure characterized by cationic residues and highly lipophilic groups, which allow it to interpose itself in the bacterial membrane, altering its structure and function.
More precisely, Chlorhexidine behaves at low concentrations like a normal detergent, destructuring the plasma membrane and compromising the cellular network, thus causing a loss of enzymatic function, at high concentrations like a real antibiotic, altering the cytoplasmic characteristics and exerting an action direct bactericide against Gram positive, Gram negative bacteria and on some species of Fungi.
The topical application and the low degree of systemic absorption make this therapy particularly safe, significantly reducing the risk of side effects and systemic complications.

Studies carried out and clinical efficacy

HYGIENE WITH CHLOREXIDINE AND DIFFICULT CLOSTRIDIUM INFECTIONS
Infect Control Hosp Epidemiol. 2012 Nov; 33: 1094-100. doi: 10.1086 / 668024. Epub 2012 Sep 21.

Effect of hospital-wide chlorhexidine patient bathing on healthcare-associated infections.

Rupp ME, Cavalieri RJ, Lyden E, Kucera J, Martin M, Fitzgerald T, Tyner K, Anderson JR, VanSchooneveld TC.


Very interesting study on hygiene in a hospital setting that shows how washing the patient with chlorhexidine before possible interventions significantly reduces the risk of hospital infection with Clostridium difficile.

CHLOREXIDINE IN THE RESUSCITATION UNITS
Nurs J India. 2012 Apr; 103: 89-91.

Decontamination with chlorhexidine gluconate reduces the incidence of ventilator associated pneumonia.

Dahiya U.


Study demonstrating how disinfection with chlorhexidine gluconate can significantly reduce the risk of pneumonia in patients with forced ventilation in resuscitation units, improving their quality of life and reducing hospitalization time.


THE USE OF CHLOREXIDINE IN ORTHOPEDIC CLINIC
J Knee Surg. 2012 Nov 12. [Epub ahead of print]

Chlorhexidine Reduces Infections in Knee Arthroplasty.

Johnson AJ, Kapadia BH, Daley JA, Molina CB, Mont MA.


Pilot study that demonstrates how premedication with chlorhexidine can be an effective method in the prevention of infections during knee arthroplasty.

Method of use and dosage

NEOXENE ®
1% and 5% chlorhexidine digluconate solution for external use;
Ovules for vaginal use of 10 ml of Chlorhexidine digluconate.
The different pharmaceutical format inevitably affects the indications of the drug and clearly the methods of use.
More precisely, the eggs are indicated for the disinfection of the vaginal mucosa, generally using one or two a day for a maximum of ten consecutive days.
The solutions for external use, indicated in the disinfection of injured skin and hands, should be applied up to 2 times a day even here for short periods.
However, the 5% solution should be diluted ten times before its use.

NEOXENE ® Chlorhexidine warnings

NEOXENE ® is a medicinal product indicated topically, therefore it should never come into contact with the eyes and exposed mucous membranes.
Disinfection or treatment protocols should be limited to short periods of time, taking care also to avoid exposure of the treated area to ultraviolet rays given the photosensitizing power of Chlorhexidine.
Should hypersensitivity reactions appear following the use of NEOXENE ®, it would be advisable to discontinue therapy immediately.
Keep the product out of the reach of children


PREGNANCY AND BREASTFEEDING

Given the absence of systemic absorption of chlorhexidine following the topical use of NEOXENE ®, there are no serious contraindications to the use of the drug during pregnancy or during breastfeeding.
However, it would be advisable to consult your gynecologist before starting the use of NEOXENE ®, in the aforementioned circumstances.

Interactions

It is recommended to avoid the simultaneous use of other antiseptics or detergents.

Contraindications NEOXENE ® Chlorhexidine

The use of NEOXENE ® is contraindicated in patients hypersensitive to the active principle or to one of its excipients.

Undesirable Effects - Side Effects

Chlorhexidine therapy may only rarely lead to the onset of adverse reactions, generally local and transient, such as redness, burning and urticaria.
In these cases, prompt discontinuation of therapy is recommended.

Note

NEOXENE ® is a drug not subject to mandatory medical prescription.


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